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The Missouri Clinicians Coalition supports Amendment 3, which would ban most abortions in Missouri except for medical emergencies, fetal anomalies, and limited cases of rape and incest up to 12 weeks. However, a significantly larger number of Missouri doctors have signed a letter opposing the amendment, and the campaign against it has more than six times the healthcare provider endorsements compared to those supporting it.

Missouri voters will decide on Amendment 3 in November 2026, which seeks to ban most abortions with some exceptions, reversing the abortion rights approved by voters in 2024. Advocates argue the exceptions in Amendment 3 are insufficient and view the measure as an abortion ban that overturns the will of Missouri voters from two years prior.

Former Missouri Attorney General Andrew Bailey has filed to form a political campaign committee named 'Vote Yes on Amendment 3' to support repealing Missouri's 2024 abortion restrictions. Amendment 3 would overturn the current ban on most abortions except in cases of medical emergencies, fetal anomaly, rape, or incest, allowing abortions only during the first 12 weeks in those exceptions.

Missouri state officials, including Gov. Mike Kehoe and Attorney General Catherine Hanaway, have appealed a Jackson County judge's June ruling that struck down several state abortion restrictions as unconstitutional under Amendment 3, the Right to Reproductive Freedom Initiative passed by Missouri voters in November 2024. The appeal, filed with the Missouri Supreme Court, challenges the ruling that allowed Planned Parenthood locations in Kansas City, St. Louis, and Columbia to provide medication abortions and contests the validity of parts of the Missouri Constitution related to abortion laws.

A Jackson County judge struck down most of Missouri's abortion restrictions, allowing medication abortions to begin and eliminating the 72-hour waiting period, while maintaining an in-person appointment requirement. Governor Mike Kehoe criticized the ruling and supports appealing to the Missouri Supreme Court, urging voters to approve an anti-abortion measure on the November 2026 ballot that would repeal the 2024 abortion-rights Amendment 3.

A Jackson County judge struck down most of Missouri's abortion restrictions, allowing medication abortions to begin and affirming prior rulings permitting procedural abortions. Missouri Attorney General Catherine Hanaway announced plans to appeal the ruling, while state lawmakers have approved a near-total abortion ban to appear on the November 2026 ballot as Amendment 3.