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Amendment 3 in Missouri includes provisions that could prevent women from receiving quality medical care and criminalize doctors, particularly in cases of ectopic pregnancies where delays in treatment can be life-threatening. The letter highlights that deaths have more than doubled in states with abortion bans, warning that Missouri's Amendment 3 could similarly endanger women's health by allowing politicians to dictate medical decisions.

Missouri voters will decide on five ballot issues on November 3, including Amendment Three, which would repeal the 2024 reproductive healthcare rights amendment and prohibit abortion and gender transition procedures for minors except in limited cases. Other measures include Amendment Six to strengthen citizen initiative protections, Amendment Seven to create a permanent public endowment fund aimed at replacing state taxes, Amendment Eight to require the election of county sheriffs, and Proposition A to uphold new congressional districts.