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Missouri pastors, led by Wesley Vance and joined by Senator Josh Hawley, unveiled a Declaration for Life at the inaugural Missouri Prayer Breakfast, calling on senators to sign a pledge against chemical abortion pills like mifepristone. Hawley introduced legislation to ban mifepristone, citing high rates of adverse effects, and challenged all senators to take the pledge, while Missouri voters prepare to decide on Amendment 3, which would repeal the 2024 abortion amendment.

In June 2026, a Kansas City judge struck down Missouri abortion clinic safety laws, including requirements for clinic inspections, informed consent, and protections for babies with Down syndrome and those able to feel pain. Similar abortion-related ballot measures are pending in Idaho, Nevada, and Virginia, with Missouri voters given a chance to repeal the 2024 abortion amendment in the November 2026 election.